This research deals with the main themes of the novel "The Fate of Man" by the French writer (Andre Malraux), namely brotherhood, death, and isolation. The incidents of this narrator, for which Malraux won the "Junkor Prize" in Shanghai in 1927, and the narrator of the destiny of man is a development that has reached an extraordinary level of perfection and mastery of the main notes of fraternity, death and isolation. Malraux was the first to insist on these themes, which are central themes in contemporary French existential literature, and the first to formulate them in his novels an elaborate artistic formulation in advance of Sartre, Cami, and Simone de Beauvoir. The heroes of Andre Malraux's novel "Human Fate" such as Keio, Katov, and Chen lived through these themes.